Name: Cyclosomatostatin
Price: 459.00 USD

- Overview
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    Background
    
    IC50: N/A
    Cyclosomatostatin is a non-selective somatostatin receptor antagonist.
    Somatostatin is a regulatory hormone or tissue factor playing an inhibitory role in the normal regulation of several organ systems including hypothalamus and pituitary gland, central nervous system, gastrointestinal tract as well as pancreas.
    In vitro: Although cyclosomatostatin could fully block the effect of somatostatin, it only partially reversed the inhibitory effect of cortistatin, a new anti-inflammatory peptide. This observation was further supported by the fact that cyclosomatostatin reversed the antiinfl ammatory effect of somatostatin and octreotide in vitro completely, while only partially reversing the effect of cortistatin [1].
    In vivo: The effect of cortistatin was found to be dose dependent, with dose as low as 0.5 nmol (50 μg/kg) being partially protective. In contrast, cyclosomatostatin, somatostatin as well as octreotide were not protective [1].
    Clinical trial: As the precursor of cyclosomatostatin, somatostatin has already been introduced in the clinical practice in some macrophage populations. Somatostatin shows protective effect in certain inflammatory disorders including pancreatitis and liver injury. However, somatostatin is not protective in lethal septic shock [1].
- Properties
  - Categories
    
    somatostatin receptor antagonist
    
    Alternative Name
    
    (3S,6R,9S,12S)-9-((1H-indol-3-yl)methyl)-6-(4-aminobutyl)-12-benzyl-3-((R)-1-(benzyloxy)ethyl)-1,4,7,10,13-pentaazacycloicosane-2,5,8,11,14-pentaone
    
    CAS Number
    
    84211-54-1
    
    Molecular Formula
    
    C44H57N7O6
    
    Molecular Weight
    
    779.98
    
    Appearance
    
    White lyophilised solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble to 1 mg/ml in 20% ethanol / H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C([[email protected]@H](CCCCN)NC([[email protected]](CC1=CNC2=CC=CC=C12)NC([[email protected]](CC3=CC=CC=C3)NC4=O)=O)=O)N[[email protected]](C(NCCCCCC4)=O)[[email protected]@H](C)OCC5=CC=CC=C5
    
    * For Research Use Only
- Reference
  - 1. Yue M, Xia et al. "Berberine ameliorates collagen-induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut." FEBS J. 2017 Sep;284(17):2786-2801. PMID:28636167

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Cyclosomatostatin

Cyclosomatostatin

Background

Documents

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