Name: Cyclo (-RGDfK)
Price: 306.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    In one study where this peptide was labeled with 125I, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. The integrin alpha(IIb)beta(3)-specific cyclic hexapeptide contains an Arg-Gly-Asp (RGD) sequence.
- Properties
  - Alternative Name
    
    Cyclo(-Arg-Gly-Asp-D-Phe-Lys); 2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
    
    CAS Number
    
    161552-03-0
    
    Molecular Formula
    
    C27H41N9O7
    
    Molecular Weight
    
    603.7
    
    Purity
    
    98.11%
    
    Solubility
    
    ≥30.19 mg/mL in DMSO; insoluble in EtOH; ≥59.2 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Yu W, Shin MR, et al. "Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling." FASEB J. 2019 Nov 2:fj201901792R. PMID:31682765
    2. Lee HN, Bosompra OA, et al. "RECK isoforms differentially regulate fibroblast migration by modulating tubulin post-translational modifications." Biochem Biophys Res Commun. 2019 Mar 5;510(2):211-218. PMID:30704758
    3. Lim C, Moon J, et al. "Cyclic RGD-conjugated Pluronic(?) blending system for active, targeted drug delivery." Int J Nanomedicine. 2018 Aug 10;13:4627-4639. PMID:30127610
    4. Schneider G, Suszynska M, et al. "Vitronectin in the Ascites of Human Ovarian Carcinoma Acts as a Potent Chemoattractant for Ovarian Carcinoma: Implication for Metastasis by Cancer Stem Cells[J]." Journal of Cancer Stem Cell Research, 2016, 4: e1005.

Cyclo (-RGDfK)

Cyclo (-RGDfK)

Background

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