Cy3.5 azide (non-sulfonated)

- Overview
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    Background
    
    Cy3.5 azide is a solid material dye ready for the use in Click Chemistry reaction. Most derivatives of non-sulfonated cyanines have low aqueous solubility except for hydrochlorides of hydrazides and amines. For biomolecule labeling, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer. Cy3.5 azide could easily interfere with a radical polymerisation process as it contains a variety of double bonds. The Cy-3 modified initiator was then used to grow the modified PMPC-PDPA directly from the dye [1].
    
    Reference: [1] Gaitzsch, J. ; Delahaye, M.; Poma, A.; Du Prez, F.; Battaglia, G. Comparison of metal free polymer-dye conjugation strategies in protic solvents. Polymer Chemistry, 2016, 7(17), 3046–3055.
- Properties
  - Categories
    
    used for Click chemistry to label alkyne-modified oligonucleotides
    
    Alternative Name
    
    3-(6-((3-azidopropyl)amino)-6-oxohexyl)-2-((1E,3E)-3-(3-butyl-1,1-dimethyl-1H-benzo[e]indol-2(3H)-ylidene)prop-1-en-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium
    
    Molecular Formula
    
    C44H53ClN6O
    
    Molecular Weight
    
    717.38
    
    Appearance
    
    A solid
    
    Purity
    
    96.24%
    
    Solubility
    
    ≥71.7 mg/mL in DMSO; insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic
    
    Storage
    
    24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
    
    SMILES
    
    CC1(C)C2=C3C(C=CC=C3)=CC=C2[N+](CCCCCC(NCCCN=[N+]=[N-])=O)=C1/C=C/C=C4C(C)(C)C5=C(C=CC=C6)C6=CC=C5N\4CCCC
    
    * For Research Use Only