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Overview
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CS Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 462 amino acids (28-466 a.a) andhaving a molecular mass of 51.4kDa. CS is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Citrate synthase also known as CS is a Krebs tricarboxylic acid cycleenzyme which catalyzes the synthesis of citrate from oxaloacetate and acetylcoenzyme A. CS is present in almost all cells capable of oxidative metabolism. CS is nuclear encoded and transported into the mitochondrial matrix, where themature form is found. The diseases related to CS are: critical illnesspolyneuropathy and mitochondrial cardiomyopathy.
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Overview