CORM-3

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Background

CORM-3 is a water-soluble carbon monoxide-releasing molecule 1.
As a CO-releasing molecule, CORM-3 can mimic the anti-allergic and anti-anaphylactic effects of heme oxygenase through the activation of the soluble guanylyl cyclase. CORM-3 is reported to have effects on cardiovascular inflammation. It reduces PMN-induced CD54 expression on EC in an in vitro model. CORM-3 also has vasoactive properties in vitro and in vivo. It shows significant vasodilatation through acting as a regulator of vessel tone and blood pressure. Besides that, CORM-3 is also a potent antimicrobial agent. It inhibits the respiration of bacterial and yeast pathogens via increasing membrane permeability and inhibiting the terminal oxidases 1,2,3,4.

1. Vannacci A, Marzocca C, Giannini L, Mazzetti L, Franchi-Micheli S, Failli P, Masini E, Motterlini R, Mannaioni PF. Evaluation of the effects of a novel carbon monoxide releasing molecule (CORM-3) in an in vitro model of cardiovascular inflammation. Inflamm Res. 2006 Apr;55.
2. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R and Motterlini R. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Cir. Res. 93:e2-e8, 2003.
3. Foresti R, Hammad J, Clark JE, Johnson TR, Mann BE, Friebe A, Green CJ, Motterlini R. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142(3):453-60.
4. Wilson JL, Jesse HE, Hughes B, Lund V, Naylor K, Davidge KS, Cook GM, Mann BE, Poole RK. Ru(CO)3Cl(Glycinate) (CORM-3): a carbon monoxide-releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coli. Antioxid Redox Signal. 2013 Aug 10;19(5):497-509.