Name: FLI-06
Price: 299.00 USD

- Overview
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    Background
    
    FLI-06 is a novel inhibitor of Notch signaling with EC50 value of 2.3uM [1]. Notch signaling plays an important role in numerous cell-fate decisions, and its aberrant activity leads to cancer and developmental disorders [1].Treatment of HeLa NotchΔE-eGFP cells with FLI-06 resulted in accumulation of NotchΔE-eGFP and reduced NICD-eGFP production. The phenotype was fully reversible within 1–4 h when washing out of FLI-06, which indicated that FLI-06 is not acutely toxic in cells [1]. In FLI-06 treated cells, Aβ secretion reduced significantly but not APPCTF accumulation, suggesting that FLI-06 acts upstream of α-secretase and β-secretase cleavage. Immunofluorescence analysis of HeLa cells revealed that FLI-06 caused a complete disruption of the Golgi, which can be caused by interfering with membrane trafficking in the early secretory pathway or by disassembly of the microtubules17. FLI-06 inhibited ER exit and also elicited the tubule-to-sheet phenotype, which are related to each other [1].
    
    [1]. Krämer A, Mentrup T, Kleizen B, et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol, 2013, 9(11): 731-738.
- Properties
  - Alternative Name
    
    cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate
    
    CAS Number
    
    313967-18-9
    
    Molecular Formula
    
    C25H30N2O5
    
    Molecular Weight
    
    438.52
    
    Appearance
    
    A solid
    
    Purity
    
    99.78%
    
    Solubility
    
    <2.69 mg/mL in EtOH insoluble in; insoluble in H2O; ≥16.1 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

FLI-06

FLI-06

Background

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