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Overview
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The C1 component of complement is a complex of 2 C1q sub-units and a tetramer comprising 2 C1r and 2 C1s sub-units. C1 activation is regulated by an inhibitor (C1 inhibitor). Reductions in the levels of components C3, C4, C1 and C2 can be associated with glomerular disease, endocarditis and systemic lupus erythematosus (SLE). C1q has a molecular weight of 410kDa.
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Overview