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Overview
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Collagen Type 0 is a chemically ancient, medical-grade fibrillar Collagen for use in tissue engineering and regenerative medicine.
As it is a non-hazardous marine-derived biomaterial, it offers a safer route to regulators by being free from the risk of disease and prions.
Studies show that Collagen Type 0 is non-immunogenic and pro-angiogenic, pro-tissue neogenic.
The essential characteristics of this fibrillar collagen are identifiable using techniques such as infrared spectroscopy, circular dichroism, amino acid analysis, and electron microscopy that highlight its triple helical structure, fibril forming capabilities and stability.
It can be formulated into various formats including liquid, powder, films, sponges, hydrogels & bioinks for a variety of biomedical applications.
Collagen is derived from the jellyfish species Rhizostoma pulmo. This unique protein predates its mammalian counterparts and, as such, has been designated as 'Collagen Type 0'.
Mammalian collagens are highly specialised and biologically complex, Collagen Type 0 however, is chemically simple, allowing greater functionality and structural versatility in various applications.
Benefits
· Versatile
Compatible with a broad range of cell types and is an ideal biomaterial for tissue engineering and regenerative medicine.
· Non Mammalian
Derived from jellyfish, avoiding religious and safety concerns over the use of mammalian collagen and disease transfer.
· Translatable
Translatable from in-vitro to in-vivo studies, due to its biocompatibility.
· Structurally Intact
Proprietary extraction technique that maintains characteristic triple helix.
· Ethically Derived
Raw materials are sourced ethically and environmentally consciously.
· Proven
Claims and performance are verified by application-specific scientific data.Please contact us at for specific academic pricing.
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- Properties
- Applications
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Overview
Biocompatibility properties of Collagen Type 0 (in vitro). Data from this study demonstrated that Collagen Type 0 did not induce secretion of NF-kB regulated cytokines TNF-α and IL-8 so does not mediate inflammation through the NF-kB pathway in dTHP-1 cells.
The differentiated THP-1 cells (both alone and when Collagen Type 0 was present) were challenged with lipopolysaccharide (LPS). LPS is a major component of gram negative bacteria and is known to trigger an inflammatory immune response. Introduction of LPS led to a marked inflammatory response, but the presence of Collagen Type 0 did not alter this in any way.
Collagen Type 0
Collagen Type 0
Catalog Number:
C001515575JEL
Mfr. No.:
JEL240001AM
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