Name: Cilazapril
Price: 290.00 USD

- Overview
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    Background
    
    Cilazapril is an inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 1.93nM [1].Cilazapril is a monoethyl prodrug of cilazaprilat. The latter shows an IC50 value of 1.93nM to rabbit lung ACE when using Hip-His-Leu substrate in vitro. Cilazaprilat is most potent among all the ACE inhibitors when the ACE is from rabbit lung, human plasma, hog kidney or human lung. Cilazaprilat is specific. It shows no inhibition to a variety of lipolytic and proteolytic enzymes even the concentration of it is up to more than 10000 fold higher than its IC50 value. Cilazapril and cilazaprilat also show inhibition of the angiotensin I (AI) pressor response with ED50 vallues of 0.44 and 0.06 mmol/kg. In addition, when cilazapril is treated as an antihypertensive drug, the maximum decrease in blood pressure relative to the control is 110mmHg on day 21 [1].
    
    [1] Waterfall JF. A review of the preclinical cardiovascular pharmacology of cilazapril, a new angiotensin converting enzyme inhibitor. Br J Clin Pharmacol. 1989;27
- Properties
  - Alternative Name
    
    (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid
    
    CAS Number
    
    88768-40-5
    
    Molecular Formula
    
    C22H31N3O5
    
    Molecular Weight
    
    417.5
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Desiccate at -20°C
    
    * For Research Use Only

Cilazapril

Cilazapril

Background

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