Choline Chloride, USP

- Overview
  - Choline Chloride is an essential nutrient commonly grouped with the B complex vitamins that plays key roles in many biological processes. Choline is found in sphingomyeline and lecithin. It is a precursor to acetylcholine. It plays a role in methyl group metabolism and can be used as a standard in methionine and choline metabolism.
    Choline Chloride is soluble in aqueous solution.
    
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    Background
    
    Choline serves as a precursor component to two major cell membrane components: phosphatidylcholine and sphingomyelin. In addition, choline also functions as a methyl group donor to several different substrates.
- Properties
  - CAS Number
    
    67-48-1
    
    Molecular Formula
    
    C5H14ClNO
    
    Molecular Weight
    
    139.62
    
    Appearance
    
    White crystalline powder
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤0.5%
    PH: 4.0-7.0
    Assay: 99.0-100.5%
    Residue On Ignition: ≤0.05%
    Heavy Metals: ≤10ppm
    Identification: UV
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Microbiology Applications: Because of its role in normal cellular processes, Choline Chloride can be used as a cell culture media supplement.
    
    Eukaryotic Cell Culture Applications: Choline was added to culture medium of in vitro-produced embryos to see if it altered the phenotype of blastocysts. Choline was found to alter the phenotype of preimplantation bovine embryos produced in vitro. Choline chlorine can act in a concentraiton-dependent manner to alter development, gene expression, and DNA methylation (ref).