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Overview
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CHO-K1 cells are derived from the ovary of an adult Chinese hamster, often used in biological and medical research and commercially in the production of therapeutic proteins. They were introduced in the 1960s, are grown as a cultured monolayer and require the amino acid proline in their culture medium. CHO-K1 cells are used in studies of genetics, toxicity screening, nutrition and gene expression, particularly to express recombinant proteins. Today, CHO cells are the most commonly used mammalian hosts for industrial production of recombinant protein therapeutics.
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