Name: CGAS Polyclonal Antibody (0.78 mg/mL) for WB, ELISA
Price: 253.00 USD

Overview
- Calculated MW: 59 kDa
  Observed MW: Refer to figures
  Gene Accession: NP612450
  
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  Background
  
  Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Synthetic peptide of human MB21D1
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  0.78 mg/mL
  
  Antigen
  
  C6orf150, cGAMP synthase, cGAS, CGAS, cGMP Synthase, Chromosome 6 open reading frame 150, Cyclic GMP-AMP synthase, h-cGAS, Hypothetical protein LOC115004, Mab 21 domain containing 1, Mab-21 domain-containing protein 1, MB21D1, MGC131892, MGC142166, MGC142168, OTTHUMP00000016743, OTTHUMP00000039330, protein MB21D1, Uncharacterized protein C6orf150 (UniProt:Q8N884)
  
  * For reference only.