Cephalonium

Cephalonium

Catalog Number:
M001341904TOK
Mfr. No.:
TOK-C246
Price:
$259
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      • Overview
        • Cephalonium is a broad-spectrum, semi-synthetic, first-generation cephalosporin antibiotic belonging to the β-lactam class. It is used against Gram-positive bacteria causing bovine mastitis.

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          Background

          Cephalosporins interfere with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases.

      • Properties
        • CAS Number
          5575-21-3
          Molecular Formula
          C20H18N4O5S2
          Molecular Weight
          458.51
          Appearance
          White to off-white powder
          Solubility
          Practically insoluble in water
          Other Properties
          Source: Semi-synthetic
          Purity Level: 95% - 103.5 % (anhydrous)
          Storage
          -20°C

          * For research use only

      • Applications
        • Application Description
          Spectrum: Effective against Gram-positive (aerobic) and select Gram-negative bacteria.

          Microbiology Applications: Cephalonium can be used in microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) and can be used as an analytical standard. MIC measurements showed that cephalonium is effective against S. epidermidis and S. caprae (Moroni et al, 2004).

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