Cefoxitin (sodium salt)

- Overview
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    Background
    
    Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. Cefoxitin, 3-carbamoyloxymethyl-7-a-methoxy-7- [2-(2-thienyl)acetamido]-3-cephem-4-carboxylic acid, is a semisynthetic cephamycin antibiotic with broad-spectrum activity. Cefoxitin is also active in vivo against a wide variety of bacteria including penicillin-resistant staphylococci and effective against gram-negative organisms including strains of indole-positive Proteus [1]. In mice, cefoxitin was more active against the cephalosporin-sensitive gram-negative bacteria, strains of E.coli, indole-producing Proteus, and Serratia, and the lactamase producing 2646. Cefoxitin was degraded by the lactamase of E. cloacae at a much slower rate than are the cephalosporins. In pharmacological studies, cefoxitin was found in sera and detected in urine samples in amounts greater than those of cephalothin and less than those of cephaloridine [1].
    
    [1]. Miller AK, Celozzi E, Kong Y, et al. Cefoxitin, a semisynthetic cephamycin antibiotic: in vivo evaluation. Antimicrob Agents Chemother. 1974 Jan;5(1):33-7.
    [2]. Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev.2009 Jan;22(1):161-82.
- Properties
  - Categories
    
    second generation cephalosporin antibiotic
    
    Alternative Name
    
    Betacef,Cenomycin,Farmoxin,Mefoxin,Merxin; (6R,7S)-3-[[(aminocarbonyl)oxy]methyl]-7-methoxy-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
    
    CAS Number
    
    33564-30-6
    
    Molecular Formula
    
    C16H16N3O7S2·Na
    
    Molecular Weight
    
    449.4
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥12.9 mg/mL in DMSO; ≥54.8 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1[[email protected]](NC(CC2=CC=CS2)=O)(OC)[[email protected]]3([H])N1C(C([O-])=O)=C(COC(N)=O)CS3.[Na+]
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Cefoxitin (sodium salt)

Background

Documents

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