Cefoxitin

- Overview
  - Cefoxitin is a cephamycin β-lactam second-generation cephalosporin. Cefoxitin is resistant to β-lactamases. Cefoxitin is sparingly soluble in aqueous solution.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephamycins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    35607-66-0
    
    Molecular Formula
    
    C16H17N3O7S2
    
    Molecular Weight
    
    427.46 g/mol
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    sparingly soluble in aqueous solution (0.195 mg/ml).
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): ≤5.0%
    PH: 2.5-3.5
    Assay: ≥98.0% (on dried basis)
    Optical Rotation: +195° to +208°
    Purity Level: 98.0-102.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefoxitin is a broad-spectrum antibiotic effective against several Gram-positive and Gram-negative bacteria. Like many cephamycins, Cefoxitin is particularly effective against anaerobic bacteria.
    
    Microbiology Applications: Cefoxitin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include: Bacteroides fragilis 1 µg/mL – 8 µg/mL Bacillus cereus 8.6 µg/mL Media Supplements Cefoxitin can be used as a selective agent in several types of isolation media: Clostridium difficile agar - Isolation of Clostridium difficile

Datasheet

MSDS

Documents

Susceptibility and Resistance Data

Media Supplements PDF-MS020

Cefoxitin

Background

Documents

We Also Recommend

Cefoxitin Sodium, USP