Name: Cefotaxime ReadyMade™ Solution
Price: 215.00 USD

- Overview
  - Cefotaxime ReadyMade™ Solution is a sterile-filtered solution of Cefotaxime Sodium, USP at a concentration of 100 mg/ml that has been dissolved in water and filter sterilized (0.2 μm) ready for use in your application. Cefotaxime Sodium is a broad-spectrum, third-generation cephalosporin and a penicillin derivative.
    
    Please contact us at for specific academic pricing.
- Properties
  - CAS Number
    
    64485-93-4
    
    Molecular Formula
    
    C16H16N5NaO7S2
    
    Molecular Weight
    
    447.45
    
    Appearance
    
    Clear and complete solution
    
    Other Properties
    
    Mechanism of Action: Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Cefotaxime Sodium however, is largely resistant to β-lactamases.
    
    Storage
    
    -20°C
    
    * For Research Use Only,
- Applications
  - Application Description
    
    Spectrum: Cefotaxime Sodium has broad-spectrum activity against a wide variety of Gram-positive and Gram-negative bacteria. However, unlike many cephalosporin antibiotics, Cefotaxime Sodium is not effective against Pseudomonas aeruginosa.
    
    Microbiology Applications: Cefotaxime Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
    Neisseria gonorrhoeae 0.008 µg/mL – 0.03 µg/mL
    Streptococcus pneumoniae ≤0.007 µg/mL － 0.25 µg/mL
    For a representative list of Cefotaxime MIC values.
    
    Plant Biology Applications: Cefotaxime is often used in Agrobacterium tumefaciens mediated transformations to combat bacterial growth. It is also sometimes used in combination with vancomycin as it has a synergistic effect.
- Reference
  - Georgopapadakou NH (1992) Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli. Antimicrob. Agents. Chemother. 37(3): 559-65 PMID 8384817
    
    Mathias RJ and Boyd LA (1986) Cefotaxime stimulates callus growth, embryogenesis and regeneration in hexaploid bread wheat (Triticum aestivum L. em Thell). Plant Sci. 46:217-223
    
    Shackelford NJ, and Chlan C (1996) Identification of antibiotics that are effective in eliminating 2 Agrobacterium tumefaciens. Plant Molec. Biology Reporter 14(1):50-57

Cefotaxime ReadyMade™ Solution

Cefotaxime ReadyMade™ Solution

We Also Recommend

Choramphenicol ReadyMade™ Aqueous Solution

Erythromycin ReadyMade™ Solution

Geldanamycin ReadyMade™ Solution