Name: Cefoselis
Price: 322.00 USD

- Overview
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    Background
    
    Cefoselis is a widely used antibiotic of β-lactam [1].Cefoselis has a large antibacterial spectrum against gram positive bacterium. It is a 4th generation of cephalosporin. Cefoselis has some side effects, such as inducing seizures and convulsion in elder and renal failure patients. Through testing the dialysate and blood samples by HPLC, it shows that cefoselis appears in the striatal dialysate samples does-dependently and disappears rapidly from the extracellular fluid. In renal failure rats, the elimination half-lives of cefoselis are prolonged. It may be one factor of the seizures caused by cefoselis. In addition, administration of cefoselis into the hippocampus causes highly increase of extracellular glutamate and slightly increase of GABA, suggesting that cefoselis induces seizures through blocking the GABA receptors [1].
    
    [1] Ohtaki K, Matsubara K, Fujimaru S, Shimizu K, Awaya T, Suno M, Chiba K, Hayase N, Shiono H. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm. 2004 Dec;111(12):1523-35.
- Properties
  - Categories
    
    β-lactam antibiotic, broad spectrum
    
    Alternative Name
    
    (6R,7R)-3-[[3-amino-2-(2-hydroxyethyl)pyrazol-1-ium-1-yl]methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
    
    CAS Number
    
    122841-10-5
    
    Molecular Formula
    
    C19H22N8O6S2
    
    Molecular Weight
    
    522.56
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=C(N4CCO)N)C(=O)[O-]
    
    * For Research Use Only