Name: Cefaclor, USP
Price: 158.00 USD

- Overview
  - Cefaclor is a second generation cephalosporin antibiotic derived from the Acremonium fungus. Cefaclor is slightly soluble in aqueous solution (8.6mg/mL).
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    70356-03-5
    
    Molecular Formula
    
    C15H14ClN3O4S • H2O
    
    Molecular Weight
    
    385.82
    
    Appearance
    
    White or off-white powder
    
    Solubility
    
    slightly soluble in aqueous solution (8.6mg/mL).
    
    Other Properties
    
    Source: Semi-synthetic
    Water Content (Karl Fischer): 3.0-6.5%
    PH: 3.0-4.5
    Assay: (Anhdrous): 950-1020 µg/mg
    Identification: IR, HPLC - Passes test
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefaclor is a broad spectrum antibiotic against Gram-negative and Gram-positive bacteria, including those that cause pneumonia and meningitis such as Streptococcus pneumoniae and Haemophilus influenzae
    
    Microbiology Applications: Cefaclor is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:Streptococcus pneumoniae 0.25 µg/mL - >64 µg/mLHaemophilus influenzae 0.25 µg/mL - >32 µg/mL
    Eukaryotic Cell Culture Applications: The interaction of Cefaclor with three human renal transporters (human organic anion transporter 1 (hOAT1), human peptide transporter 1 (hPepT1), and human peptide transporter 2 (hPepT2)) was studied.. Madin-Darby canine kidney cell lines expressing these transporters were established. Cefaclor was found to be transported by hPepT1 and hPepT2. (Li et al, 2006)