Caspofungin Acetate

- Overview
  - Caspofungin Acetate is a lipopeptide echinocandin antifungal which specifically targets the fungal cell membrane. It is semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. As a β-1,3-D-glucan synthesis antagonist, the compound is used to study the effect of environmental and chemical stress on fungal survival. Caspofungin is an analog of pneumocandin B0. Caspofungin Acetate is sparingly soluble in water and slightly soluble in ethanol.
    
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    Background
    
    Caspofungin acts as an inhibitor of β(1,3)-D-Glucan synthase, an enzyme required for cell wall synthesis. Inhibition of this enzyme results in a disruption of the fungal cell wall integrity.
- Properties
  - CAS Number
    
    179463-17-3
    
    Molecular Formula
    
    C52H88N10O15 • 2C2H4O2
    
    Molecular Weight
    
    1213.42
    
    Appearance
    
    White to off-white powder
    
    Solubility
    
    Sparingly soluble in water. Slightly soluble in ethanol.
    
    Other Properties
    
    Source: Semi-synthetic; derived from a fermentation product of the fungus Glarea lozoyensis.
    Water Content (Karl Fischer): ≤10.0%
    PH: 5.9-6..7
    Assay: (As Is): 94.5-102.5%
    Heavy Metals: ≤20 ppm
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Caspofungin Acetate is effective against yeasts and molds including Candida and Aspergillus spp.
    
    Microbiology Applications: Caspofungin MIC is ≤ 1 µg/ml for Candida.
    For additional MIC data on Candida or other fungi, please consult our Antimicrobial Index.