Canine, Human, Monkey, Mouse, Rat, Salamander PDGF-AA Recombinant Protein (Animal Free) Lyophilized

Canine, Human, Monkey, Mouse, Rat, Salamander PDGF-AA Recombinant Protein (Animal Free) Lyophilized

Catalog Number:
P001418840INN
Mfr. No.:
ICNHUMNMSRTSMPDGFAARAFLY2UG
Price:
$613
  • Size:
    2UG
    Quantity:
    Add to Cart:
      • Overview
        • Canine, Human, Monkey, Mouse, Rat, Salamander PDGF-AA Recombinant Protein (Animal Free) Lyophilized from Innovative Research has been recombinantly produced in E. coli. This is a Lyophilized protein buffered in with a purity of ? 98% by SDS-PAGE gel and HPLC analyses.

          Please contact us at for specific academic pricing.

          Background

          PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet ?-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-? and PDGFR-?. PDGFR-? is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-? interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AA is a 28.5 kDa disulfide-linked homodimer of two A chains (250 total amino acids).

      • Properties
        • Protein Name
          PDGFA
          Source
          E. coli
          Type
          Animal Free Proteins
          Purification
          >98% by SDS-PAGE gel and HPLC analyses.
          Storage
          The recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing the recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

          * These products are supplied for manufacturing, research and laboratory use only.

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