Candesartan

- Overview
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    Background
    
    Angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a pro-drug candesartan cilex
- Properties
  - Categories
    
    Angiotensin II receptor 1 (AT1) antagonist
    
    Alternative Name
    
    2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
    
    CAS Number
    
    139481-59-7
    
    Molecular Formula
    
    C24H20N6O3
    
    Molecular Weight
    
    440.45
    
    Appearance
    
    A solid
    
    Purity
    
    99.01%
    
    Solubility
    
    insoluble in H2O; ≥14.65 mg/mL in DMSO; ≥3.45 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O
    
    * For Research Use Only
- Reference
  - 1. Rui-Juan Gao, Ai-Mei Zhang, et al. "The promoting role of Cx43 on the proliferation and migration of arterial smooth muscle cells for angiotensin II-dependent hypertension." Pulm Pharmacol Ther. 2021 Oct;70:102072. PMID:34428599