Cabazitaxel

Cabazitaxel

Catalog Number:
L002370327APE
Mfr. No.:
APE-B2157
Price:
$241
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      • Overview
        • Please contact us at for specific academic pricing.

          Background

          Cabazitaxel(XRP6258; RPR-116258A) is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

      • Properties
        • CAS Number
          183133-96-2
          Molecular Formula
          C45H57NO14
          Molecular Weight
          835.93
          Appearance
          A solid
          Purity
          99.29%
          Solubility
          ≥22.3 mg/mL in DMSO; insoluble in H2O; ≥26.6 mg/mL in EtOH
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference
        • 1. Sarah D. Burnett, Alexander D. Blanchette, et al. "Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors." Chem Res Toxicol. 2021 Sep 20;34(9):2110-2124. PMID:34448577
          2. Choi B, Jung H, et al. "Sequential MR Image-Guided Local Immune Checkpoint Blockade Cancer Immunotherapy Using Ferumoxytol Capped Ultralarge Pore Mesoporous Silica Carriers after Standard Chemotherapy." Small. 2019 Nov 7:e1904378. PMID:31697036
          3. Su F, Ahn S, et al. "Adipose stromal cell targeting suppresses prostate cancer epithelial-mesenchymal transition and chemoresistance." Oncogene. 2018 Oct 25. PMID:30361686
          4. Blanchette AD, Grimm FA, et al. "Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships." Clin Pharmacol Ther. 2018 Oct 22. PMID:30346629
          5. Oblad RV, Doughty H, et al. "Application of Mixture Design Response Surface Methodology for Combination Chemotherapy in PC-3 Human Prostate Cancer Cells." Mol Pharmacol. 2018 Jun 8. pii: mol.117.111450. PMID:29884690

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