Name: Butyrolactone 3
Price: 196.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    IC50: 100 μM
    Butyrolactone 3 is a histone acetyltransferase Gcn5 inhibitor.
    The human histone acetyltransferase Gcn5 is identified as a prominent member of the GNAT family with high preference for histone H3 as a substrate.
    In vitro: The analogs of butyrolactone 3 only showed a weak inhibition of CBP, while butyrolactone 3 led to an inhibition of Gcn5. It was important to see that in the presence of acetyl-CoA the Kd value for binding of histone H3 to Gcn5 or PCAF was around 100 mM. Moreover, the affinity of butyrolactone 3 to the Gcn5 enzyme was found to be comparable to that of the natural substrate H3 and could provide an good starting point for the study of SAR. In addition, a nonirreversible inhibition of Gcn5 could be determine, and thus a Michael addition of nucleophilic groups of the enzymeBs active side was unlikely. Therefore, the derivatization of gbutyrolactone 3 at position 2 might be a promising starting point for future SAR studies [1].
    In vivo: So far, there is no animal in vivo data reported.
    Clinical trial: Up to now, Butyrolactone 3 is still in the preclinical development stage.
- Properties
  - Alternative Name
    
    rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid
    
    CAS Number
    
    778649-18-6
    
    Molecular Formula
    
    C9H12O4
    
    Molecular Weight
    
    184.2
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95.00%
    
    Solubility
    
    ≤14mg/ml in ethanol;14mg/ml in DMSO;13mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

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Butyrolactone 3

Butyrolactone 3

Background

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