Name: Bulk anti-Human CCR5 antibody (HEK/1/85a/7a) Low Endotoxin
Price: 832.00 USD

- Overview
  - Antigen Distribution: CCR5 is expressed on memory T cells, macrophages, and immature dendritic cells (DCs)
    Specificity: Clone HEK/1/85a/7a recognizes an epitope on human CCR5
    Purification method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
    Isotype Control: Rat IgG2b In Vivo Isotype Control - Low Endotoxin [1-2] (ICH2243)
    Endotoxin: ≤ 0.75 EU/mg as determined by the LAL method
    Aggregation: Aggregation level ≤ 1%
    
    Please contact us at for specific academic pricing.
    
    Background
    
    CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection. CCR5 also contributes to other human diseases, including type I diabetes and cancer.
- Properties
  - Host
    
    rat
    
    Isotype
    
    IgG2b kappa
    
    Reactivity
    
    human
    
    Clone
    
    HEK/1/85a/7a
    
    Immunogen
    
    CHO cells transfected with full-length human CD195 (CCR5).
    
    Purification
    
    >98% by SDS-PAGE and HPLC
    
    Formulation
    
    This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
    
    Storage
    
    This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
    
    Molecular Weight
    
    ≥ 5.0 mg/ml
    
    Regulatory Status
    
    The suggested concentration for this CD195 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 10^6 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.
    
    Antigen
    
    (Gene ID:C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor, CD195)
    
    * Products are for research use only. Not for use in diagnostic or therapeutic procedures.
- Applications
  - Application
    
    Flow Cytometry; Immunocytochemistry

Bulk anti-Human CCR5 antibody (HEK/1/85a/7a) Low Endotoxin

Bulk anti-Human CCR5 antibody (HEK/1/85a/7a) Low Endotoxin

Background

We Also Recommend

Anti-Mouse Fas Ligand In Vivo Antibody - Ultra Low Endotoxin (MFL3)

Anti-Mouse MHC Class II In Vivo Antibody - Ultra Low Endotoxin (M5/114.15.2)

Bulk anti-Human CD1d antibody -Ultra Low Endotoxin (D5)