Name: BTZO 1
Price: 397.00 USD

- Overview
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    Background
    
    BTZO 1 binds to migration inhibitory factor (MIF) with a Kd of 68.6 nM [1].MIF is a ubiquitous protein. It is a specific BTZO 1-binding protein. MIF is released by ischemic heart tissue. It activates the cardioprotective AMP-activated protein kinase (AMPK) pathway. MIF was reported to be a key upstream regulator of the innate and acquired immune response. MIF regulates cytokine secretion, counter-regulates glucocorticoids in inflammation, inhibits oxidative stress-induced cell death, and activates components of the Jun-activation domain-binding protein-1 (Jab-1) pathway and mitogen-activated protein kinase [1].H9c2 cells transfected by pGL3-ARE-Luc were treated with rMIF in the presence of BTZO 1 at 1 µM. In this system, dose-dependently induced luciferase activity was found. When transfected cells were treated with rMIF alone, ARE-mediated luciferase activity was scarcely induced. Treatment with BTZO 1, also promoted rMIF induction of HO-1 mRNA and GST Ya in H9c2 cells. In H9c2 cells, pretreatment with BTZO 1 at 30 µM caused an approximately 20% decrease in tautomerase activity (measured in the cell lysate). This suggested that there was a direct interaction between MIF and BTZO 1 in H9c2 cells [1].BTZO 2 is a BTZO 1 analog with a better ADME profile. 24 hr after reperfusion with drug, mean values for the area at risk were 46% ± 3% and 48% ± 2% for vehicle and BTZO 2, respectively. In control rats, left anterior descending coronary artery (LAD) occlusion and reperfusion caused an infarct size of 43% of the area at risk. Compared to control, intraperitoneal administration with BTZO 2 at 10 mg/kg 1 hr prior to LAD occlusion and 2 and 8 hr after reperfusion caused an approximately 45% reduction in the infarct size [1].
- Properties
  - Alternative Name
    
    2-(pyridin-2-yl)-4H-benzo[e][1,3]thiazin-4-one
    
    CAS Number
    
    99420-15-2
    
    Molecular Formula
    
    C13H8N2OS
    
    Molecular Weight
    
    240.28
    
    Appearance
    
    Golden Yellow crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in DMSO
    
    Storage
    
    Store at RT
    
    * For Research Use Only

BTZO 1

BTZO 1

Background

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