BNP Fragment ELISA (Nt-proBNP 8-29)

Brain natriuretic peptide (BNP) is a cardiac peptide hormone that plays an important role in the regulation of cardiovascular and renal homeostasis, fatty acid metabolism, and body weight. It is secreted in response to volume overload and increased filling pressure.
BNP is cleaved into smaller fragments: active BNP-32 and inactive nt-proBNP (1-76) which contains the 8-29 amino acid sequence which the antibodies in the ELISA recognize. BNP fragments are typically measured as a proxy for BNP because of their longer half-life.
Recent research suggests that natriuretic peptides are important protectors against fluid overload and high blood pressure. BNP has also been implicated as a valuable marker in assessing cardiac risk.
Research area interests include cardiac impairment, acute myocardial infarction, renal failure, diabetes, obesity, and various forms of secondary hypertension.

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