Name: BMP2pp
Price: 298.00 USD

- Overview
  - BMP-2 mimetic.
    BMP2pp is a peptide corresponding to residues 73-92 of the knuckle epitope of bone morphogenetic protein-2 (BMP-2) which inhibits the binding of human recombinant BMP-2 to both BMP receptors type IA and type II. BHP2pp has the same receptor binding capacity and osteogenic properties as the full BMP-2 protein and can promote the formation and regeneration of bone and cartilage, participate in organogenesis, cell differentiation, cell proliferation and apoptosis, but is more stable. In models of artificial joint replacement wear, BMP2pp can ameliorate the Titanium (Ti) mediated impairment in osteogenic potential of human placenta derived mesenchymal stem cells (hPMSCs), suppress the M1 polarization of macrophages through inhibition of the activation of the NF-κB signaling pathway, and ameliorate Ti-induced bone osteolysis. The sequence with a GGC linker at the C teminal, BMP-2 derived peptide , is also available.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    Bone morphogenetic protein-2 functional polypeptide, 73-92 peptide
    
    Molecular Formula
    
    C97H164N22O30
    
    Molecular Weight
    
    2117.2
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Lys-Ile-Pro-Lys-Ala-Ser-Ser-Val-Pro-Thr-Glu-Leu-Ser-Ala-Ile-Ser-Thr-Leu-Tyr-Leu-OH,KIPKASSVPTELSAISTLYL
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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