Name: BML-210(CAY10433)
Price: 230.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    BML-210 (CAY10433) is a novel HDAC inhibitor with IC50 value of 87 μM [1]. Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from ε-N-acetyl lysines on histones, allowing the histones to wrap the DNA more tightly. DNA expression is regulated by de-acetylation and acetylation. BML-210 (CAY10433) is a novel HDAC inhibitor. In FRDA lymphoid cell line (GM15850), BML-210 increased the level of FXN mRNA by 1.4-fold [1]. In the human leukemia cell lines (NB4, HL-60, THP-1, and K562), BML-210 induced G1 arrest and histone H4 acetylation, affected NF-κB and Sp1 binding to the p21 or the FasL promoters, and influenced expression of Sp1, NF-κB, p21 and FasL. BML-210 inhibited cell growth and induced apoptosis in a time- and dose-dependent way. BML-210 also induced K562 and HL-60 cell differentiation (up to 30%) to erythrocytes and granulocytes, respectively [2]. In HeLa cells, BML-210 (20 or 30 μM) increased the amount of cells in G0/G1 phase, caused sub-G1 accumulation, and induced apoptosis [3]. In human promyelocytic leukemia NB4 cells, BML-210 inhibited cell growth in a dose- and time-dependent way [4].
    
    [1]. Herman D, Jenssen K, Burnett R, et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006, 2(10): 551-558.
    [2]. Savickiene J, Borutinskaite VV, Treigyte G, et al. The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. Eur J Pharmacol, 2006, 549(1-3): 9-18.
    [3]. Borutinskaite VV, Magnusson KE, Navakauskiene R. Histone deacetylase inhibitor BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Mol Biol Rep, 2012, 39(12): 10179-10186.
    [4]. Borutinskaitė V, Navakauskienė R. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Int J Mol Sci, 2015, 16(8): 18252-18269.
- Properties
  - Alternative Name
    
    (1Z,8Z)-N'1-(2-aminophenyl)-N'8-phenyloctanebis(imidic acid)
    
    CAS Number
    
    537034-17-6
    
    Molecular Formula
    
    C20H25N3O2
    
    Molecular Weight
    
    339.43
    
    Appearance
    
    A solid
    
    Purity
    
    98.26%
    
    Solubility
    
    insoluble in H2O; ≥10.5 mg/mL in DMSO; ≥4.01 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

BML-210(CAY10433)

BML-210(CAY10433)

Background

We Also Recommend

2-hexyl-4-Pentynoic Acid

Sanguinarine chloride

Triacetyl Resveratrol