Name: 2-hexyl-4-Pentynoic Acid
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    2-hexyl-4-Pentynoic Acid is a potent and robust inhibitor of HDAC with IC50 value of 13 μM [1]. Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from ε-N-acetyl lysines on histones, allowing the histones to wrap the DNA more tightly. DNA expression is regulated by de-acetylation and acetylation. 2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor. In cerebellar granule cells, 2-hexyl-4-Pentynoic Acid (5 μM) significantly and dose-dependently increased acetylated histone H3 (Ac-H3) levels, and at 50-100 μM led to a maximal increase of 600-700%, compared with only a 200% increase by VPA at 100 μM. 2-hexyl-4-Pentynoic Acid also completely blocked glutamate-induced cell death at 50-100 μM. Also, 2-hexyl-4-Pentynoic Acid restored glutamate-induced neuronal loss. At 50 μM, 2-hexyl-4-Pentynoic Acid effectively increased HSP70-1a and HSP70-1b mRNA levels through HDAC inhibition [1].
- Properties
  - Alternative Name
    
    2-(prop-2-yn-1-yl)octanoic acid
    
    CAS Number
    
    96017-59-3
    
    Molecular Formula
    
    C11H18O2
    
    Molecular Weight
    
    182.26
    
    Appearance
    
    A colorless liquid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥15.45 mg/mL in DMSO; ≥51.8 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Zhao J, Chen C, et al. "Identification of HIVEP2 as a dopaminergic transcription factor related to substance use disorders in rats and humans." Transl Psychiatry. 2019 Oct 4;9(1):247. PMID:31586043