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Overview
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Target: CD19
Tag: C-Flag&Avi Tag
Synonyms: B4; CVID3
Protein Families: Druggable Genome, Transmembrane
Protein Pathways: B cell receptor signaling pathway, Hematopoietic cell lineage, Primary immunodeficiencyPlease contact us at for specific academic pricing.
Background
A member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections.
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- Properties
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Overview
Biotinylated Human CD19 full length protein-PeptiNanodisc
Biotinylated Human CD19 full length protein-PeptiNanodisc
Catalog Number:
P001561530DIM
Mfr. No.:
FLP400499B
Price:
$1,225
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