Biotin-dPEG®₂₃-NH₂

- Overview
  - Biotin-dPEG®23-NH2 (Biotin-dPEG®23-amine), product number 10786, is one of several carbonyl- and carboxylic acid-reactive biotinylation products offered by Quanta BioDesign, Ltd. Biotin-dPEG®23-NH2 reacts with activated esters (N-hydroxysuccinimide, 2,3,5,6-tetrafluorophenyl) of carboxylic acids under slightly basic conditions. Moreover, it can be coupled directly to a carboxylic acid using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry. Additionally, the product reacts with aldehydes or ketones to form a Schiff base. The Schiff base can be reduced to a secondary amine using sodium cyanoborohydride if additional conjugate stability is necessary.
    
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- Properties
  - Categories
    
    Biotinylation Reagents
    
    CAS Number
    
    604786-74-5
    
    Molecular Weight
    
    1299.60; single compound
    
    Purity
    
    > 95%
    
    Other Properties
    
    dPEG® Spacer is 71 atoms and 87.0 Å
    
    * For Research Use Only
- Reference
  - Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 529-530 for a general discussion in Greg’s book and on biotinylation as well, as well as pp. 737-738 for a protocol for a compound with just two oxygen. However, other than enhanced solubility and binding distances, the protocol is adaptable to our PN 10193.

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Biotin-dPEG®₂₃-NH₂

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