BioCore SCX Column

Biocore Ion-Exchange columns are widely used in the separation of proteins and many other biomolecules.

Main characteristics:
• High column efficiency, good selectivity and high separation
• Precise control of microsphere size and excellent performance and consistency between pillars produced by advanced surface bonding processes
• Excellent Pressure Stability with High Crosslinking Degree and High Mechanical Strength
• Wide selectivity range and can be used for separation and analysis of many different biological molecules.

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Background

IEX is a commonly used separation mode, which separates molecules based on the difference in the ionic groups on the protein surface. In IEX chromatography, elution is performed using either a salt- or pH-based gradient, which elutes the bound protein by disrupting the electrostatic interactions between the protein and the stationary phase. When traditional salt-based gradients have been employed, significant method development is required to get optimal resolution of charge variants contained in different mAb samples. pH-based gradients have gained popularity, primarily for their more generic applicability across different mAbs.

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