BioCore HIC LC Column

BioCore HIC-Butyl is a family of high-performance, hydrophobic interaction chromatography columns that separate monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) based on their differences in surface hydrophobicity.

Main Features
• Optimal selectivity for the DAR analysis in ADCs
• Minimal undesired interactions for low carryover
• Excellent mechanical strength for column robustness
• Good column-to-column consistency

Hydrophobic interaction chromatography (HIC) is a traditional technique used for the separation, purification, and characterization of proteins. As the number of antibody-drug conjugates (ADCs) continues to increase in development of bio-therapeutics, HIC and RP methods, both utilizing changes in hydrophobicity for separation, are often used for ADC characterization and analysis. Unlike RP technique, HIC uniquely allows for protein analysis under mild nondenaturing conditions that preserve the native structure and activity of the molecules, thus analysis of the ADC in its native form is advantageous.

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