Name: Bilobalide
Price: 180.00 USD

- Overview
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    Background
    
    Description:
    IC50 Value: 3.33 (pIC50 Value) [1]
    Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. An increasing number of studies have demonstrated its neuroprotective effects.
    in vitro: Inhibition by BB and GB was abolished in mutant receptors containing T6'S and S12'A substitutions, but their potencies were enhanced (42- and 125-fold, respectively) in S2'A mutant receptors [1]. BB enhanced the secretion of α-secretase-cleaved soluble amyloid precursor protein (sAPPα, a by-product of non-amyloidogenic processing of APP) and decreased the β amyloid protein (Aβ, a by-product of amyloidogenic processing of APP) via PI3K-dependent pathway [2].
    in vivo: Oral administration of bilobalide (10-30 mg/kg) significantly inhibited thermal hyperalgesia in response to carrageenan, capsaicin and paw incision, independent of dose, with an efficacy similar to that of diclofenac. In the carrageenan model, mechanical hypersensitivity and paw oedema were also significantly reduced after treatment with bilobalide (10-30 mg/kg) [3]. BB(4 and 8 mg/kg) significantly protected VD rats against cognitive deficits in the Morris water maze. Biochemical assessment showed that BB (4 and 8 mg/kg) increased superoxide dismutase (SOD) activity and glutathione (GSH) content, and decreased nitric oxide synthase (NOS) activity and malondialdehyde (MDA) content [4].
    Clinical trial: N/A
- Properties
  - Categories
    
    Neuroprotective agent
    
    Alternative Name
    
    (-)-Bilobalide
    
    CAS Number
    
    33570-04-6
    
    Molecular Formula
    
    C15H18O8
    
    Molecular Weight
    
    326.3
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥16.32 mg/mL in DMSO; ≥50.2 mg/mL in EtOH with gentle warming
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1O[[email protected]]([[email protected]]([[email protected]@](C2([H])[H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])O[H])([[email protected]@]3([H])O[H])[[email protected]](C4([H])[H])1[[email protected]@]2([H])OC4=O)([H])OC3=O
    
    * For Research Use Only