(+)-Bicuculline

- Overview
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    Background
    
    GABAA receptor antagonist; blocks Ca2+-activated potassium (SK) channels. Water soluble derivative of (+)-bicuculline
- Properties
  - Categories
    
    GABAA receptor antagonist, competitve and classical
    
    Alternative Name
    
    Bucuculline; (6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
    
    CAS Number
    
    485-49-4
    
    Molecular Formula
    
    C20H17NO6
    
    Molecular Weight
    
    367.11
    
    Appearance
    
    A solid
    
    Purity
    
    99.80%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥13.1 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN([[email protected]@H]1[[email protected]]2C(C=CC3=C4OCO3)=C4C(O2)=O)CCC(C1=C5)=CC6=C5OCO6
    
    * For Research Use Only