beta-Nicotinamide mononucleotide

- Overview
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    Background
    
    beta-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide[1].
    In a Nampt+/- mouse model of metabolic disease, β-NMN (50-100 µM) has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion, demonstrating a role for Nampt in β cell function[2].
    Furthermore, at 500 mg/kg/day, β-NMN has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels[3].
    
    [1]. Gallí M, Van Gool F, Rongvaux A, et al. The nicotinamide phosphoribosyltransferase: A molecular link between metabolism, inflammation, and cancer. Cancer Research, 2010, 70: 8-11.
    [2]. Revollo J R, Körner A, Mills K F, et al. Nampt/PBEF/visfatin regulates insulin secretion in Β cells as a systemic NAD biosynthetic enzyme. Cell Metabolism, 2007, 6(5): 363-375.
    [3]. Yoshino J, Mills K F, Yoon M J, et al. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism, 2011, 14(4): 528-536.
- Properties
  - Categories
    
    Intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+)
    
    Alternative Name
    
    ((2R,3S,4R,5R)-3,4-dihydroxy-5-(3-(hydroxy(imino)methyl)pyridin-1-ium-1-yl)tetrahydrofuran-2-yl)methyl hydrogen phosphate
    
    CAS Number
    
    1094-61-7
    
    Molecular Formula
    
    C11H16N2O8P
    
    Molecular Weight
    
    334.22
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥33.4 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    N=C(O)C1=C[N+]([[email protected]@]2([H])[[email protected]@](O)([H])[[email protected]@](O)([H])[[email protected]@](O2)([H])COP(O)([O-])=O)=CC=C1
    
    * For Research Use Only
- Reference
  - 1. Peng, Tianqing. "Nicotinamide mononucleotide imparts protection against Doxorubicin-induced cardiotoxicity by maintaining lysosomal acidification." Western University, 8-4-2020.

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

beta-Nicotinamide mononucleotide

beta-Nicotinamide mononucleotide

Background

Documents

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