Name: Cytidine 5-triphosphate
Price: 180.00 USD

- Overview
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    Background
    
    Cytidine 5-triphosphate (CTP) is a pyrimidine nucleoside triphosphate involved in many biochemical reactions, including RNA synthesis, the formation of phosphatidylcholine (PC), and sialylation. In PC synthesis, CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce cytidine diphosphate-choline (CDP-choline) and diphosphate. This is the rate-limiting step in PC synthesis, and has been implicated in the provision of membranes and bioactive lipids necessary for cell proliferation, contributing to malignant transformation of intestinal epithelial cells. CTP also interacts with N-acylneuraminate in a reaction catalyzed by N-acylneuraminate cytidylyltransferase, generating an intermediate required for sialylation, namely cytidine 5-monophosphate-N-acylneuraminic acid.
    
    1. Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. Journal of Lipid Research, 2008, 49(6): 1187-1194.
    2. Lagace TA, Ridgway ND. The role of phospholipids in the biological activity and structure of the endoplasmic reticulum. Biochimica et Biophysica Acta, 2013, 1833(11): 2499-2510.
    3. Arsenault DJ, Yoo BH, Rosen KV, et al. ras-Induced up-regulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells. Journal of Biological Chemistry, 2013, 288(1): 633-643.
    4. Vionnet J, Concepcion N, Warner T, et al. Purification of CMP-N-acetylneuraminic acid synthetase from bovine anterior pituitary glands. Glycobiology, 1999, 9(5): 481-487.
- Properties
  - Categories
    
    A pyrimidine nucleoside triphosphate, a substrate in the synthesis of RNA
    
    Alternative Name
    
    ((2R,3S,4R,5R)-3,4-dihydroxy-5-(2-hydroxy-4-iminopyrimidin-1(4H)-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
    
    CAS Number
    
    65-47-4
    
    Molecular Formula
    
    C9H16N3O14P3
    
    Molecular Weight
    
    483.16
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥48.3 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    N=C1C=CN(C(O)=N1)[[email protected]@]2([H])[[email protected]@](O)([H])[[email protected]@](O)([H])[[email protected]@](O2)([H])COP(O)(OP(O)(OP(O)(O)=O)=O)=O
    
    * For Research Use Only