BcMag™ One-Step Detergent Removal Kit

Detergents (surfactants) are essential for biomedical research. For successful downstream analysis, it is critical to reduce or entirely remove unbound detergents from the biological sample. However, excess unbound detergent is usually poorly compatible with many downstream applications, including ELISA, protease digestion of proteins, isoelectric focusing, and mass spectrometry (MS). Several commercially available detergent removal methods include prolonged dialysis, anion exchange chromatography, detergent removal spin column, and acetone precipitation. However, these procedures, such as using detergent removal columns, are either laborious or suffer from sample losses and are challenging for low volume samples and high thorough-put automation. We developed a novel, efficient surfactant removal system to overcome these limitations. BcMag™ One-Step Detergent Removal Kit uses magnetic resin coated with proprietary chemistry to remove detergents. Compared with the detergent removal columns, the resin can quickly and efficiently remove free detergents from the sample with just a single step and enables individual samples or 96 samples to be processed simultaneously in less than 1 minute or 10 minutes with 95% sample recovery. Since the magnetic resin only adsorbs the detergent, the sample recovery rate is exceptional 90%-95%.

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