Name: BW 373U86
Price: 705.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Ki: 1.8, 15, 85 and 34 nM for delta, mu, epsilon and kappa receptor
    Opioid receptors are heterogeneous and at least four types, mu,.delta, kappa and epsilon, are known to exist. Currently, all clinically used opiates act through the mu receptor to induce analgesia; however, they also induce unwanted side effects such as respiratory depression, dependence, constipation and muscle rigidity.BW 373U86 is a novel, potent and selective nonpeptidic delta opioid receptor agonist. In vitro: BW 373U86 was a potent delta receptor-selective ligand in receptor binding assays. The Ki values were 1 .8 ± 0.4, 15 ± 3, 85 ± 4 and 34 ± 3 nM for delta, mu, epsilon and kappa receptor binding sites, respectively. BW 373U86 inhibited electncally evoked muscle contraction of mouse vas deferens with an ED50 value of 0.2 ± 0.06 nM [1]. In vivo: BW 373U86 inhibited the acoustic startle reflex after subcutaneous administration from 0.2- to 2-mg/kg doses in rats, and this inhibition was blocked by naltnndole. BW 373U86 also induced a dose-dependent increase of locomotor activity in rats at similar doses. This effect was inhibited by naltnndole [3].
    Clinical trial: Up to now, BW 373U86 is still in the preclinical development stage.
- Properties
  - Categories
    
    Non-peptide delta agonist, potent and selective
    
    Alternative Name
    
    4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide
    
    CAS Number
    
    155836-50-3
    
    Molecular Formula
    
    C27H37N3O2
    
    Molecular Weight
    
    435.61
    
    Appearance
    
    Beige solid
    
    Purity
    
    98.00%
    
    Solubility
    
    <43.56mg/ml in 1eq. HCl
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    OC1=CC([[email protected]@H](C2=CC=C(C(N(CC)CC)=O)C=C2)N3[[email protected]@H](C)CN(CC=C)[[email protected]](C)C3)=CC=C1
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

BW 373U86

BW 373U86

Background

Documents

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