Azido-dPEG®₄-OH

Azido-dPEG®4-OH (Azido-dPEG®4-alcohol), product number 10541, is a click chemistry reagent used to modify surfaces and biomolecules or to crosslink with other surfaces or biomolecules. This product consists of an azide and a terminal hydroxy group separated by a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. The terminal azide reacts in copper(I)-catalyzed, ruthenium-catalyzed, and strain-promoted azide-alkyne cycloaddition reactions (CuAAC, RuAAC, and SPAAC, respectively). If left unmodified, the alcohol group increases the water solubility and hydrodynamic volume of molecules and surfaces to which it is conjugated. Modifying the alcohol with a reactive group such as chloride, tosylate, or mesylate allows Azido-dPEG®4-OH to function as a crosslinker through subsequent chemical manipulations.


OurdPEG® Crosslinkers
Polyethylene glycol (PEG) products are widely renowned for the unique chemical and physical properties that they impart to conjugate molecules. These imparted properties include

increased hydrodynamic volume;
improved water solubility for hydrophobic small molecules and biomolecules;
reduced or eliminated hydrophobic and non-specific interactions that lead to background "noise" in diagnostic tests or aggregation and precipitation of biomolecular conjugates; and,
reduced or eliminated immunogenicity of large biomolecular conjugates.

Unlike polymeric PEG products, which contain a wide range of PEG chain lengths and molecular weights, our dPEG® products are unique. These are monodispersed PEG products made by careful, step-wise synthesis using synthetic organic chemistry methods

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