Azido-dPEG®₂₃-amine

Azido-dPEG®23-amine, product number 10525, is a carbonyl-reactive, biocompatible crosslinking reagent that can participate in multiple types of reactions. The product consists of an azide group and an amine group on opposite ends of a single molecular weight, discrete polyethylene glycol (dPEG®) chain. The azide reacts with alkynes in copper-catalyzed, ruthenium-catalyzed, and strain-promoted click chemistry to yield triazole derivatives. Moreover, the azide group functions as a masked amine that reduces to a primary amine via a suitable reducing agent. Furthermore, Azido-dPEG®23-amine can participate in a Staudinger ligation with appropriate phosphine derivatives to create a water-soluble product.


dPEG® Technology Makes a Difference in PEGylation
Quanta BioDesign invented discrete PEG technology. We manufacture and sell our products under the dPEG® trade name. Our products provide all of the benefits of conventional PEG linkers and spacers, including increased water solubility, increased hydrodynamic volume, improved biodistribution and pharmacokinetic profiles in vivo, reduction or elimination of immunogenicity of conjugated molecules, and many more. However, our products have no dispersity, unlike traditional polymer PEG products. Thus, our products eliminate the analytical difficulties that traditional PEG products produce.

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