Azido-dPEG®₂₄-acid

Azido-dPEG®24-acid, product number 10514, is a click chemistry reagent. The azide moiety on one end of the molecule can be used for copper(I)-catalyzed click chemistry or copper free click chemistry. Between the azide moiety and the propanoic acid moiety on the other end of the molecule is a single molecular weight, discrete polyethylene glycol (dPEG®) spacer. The propanoic acid moiety can be coupled to a primary or secondary amine through an acylation reaction.

Click chemistry enables rapid, chemoselective, stereospecific reactions between an azide and an alkyne leading to the formation of a triazole ring that joins the two reacted molecules. Since its discovery in 1998 and publication in 2001, click chemistry has grown consistently in popularity and importance for the development of new chemical structures. The first-reported click chemistry reactions were catalyzed by copper(I) and are known as Cu(I)-catalyzed azide alkyne cycloaddition (CuAAC). Subsequently, copper free click chemistry (formally known as strain promoted azide alkyne cycloaddition, or SPAAC) was developed so as to facilitate click chemistry reactions in living cells without the use of toxic copper salts.

OurdPEG® products are single molecular weight products. Unlike traditional, polymeric polyethylene glycol (PEG), dPEG® products contain a single molecular weight PEG chain with a discrete chain length. The use of dPEG® instead of traditional polymer PEG allows accurate characterization of conjugates without sacrificing any of the benefits of PEG.

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