Name: AZD0156
Price: 209.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    AZD0156 is an ATM kinase inhibitor.Ataxia telangiectasia mutant (ATM), a serine/threonine protein kinase from the phosphatidylinositol 3-kinase-related kinase (PIKK) family of protein kinases, plays a critical role in the cellular DNA damage response signalling activated by DNA double strand breaks. Activated ATM can promote DNA repair and S/G1-cell cycle checkpoints to prevent premature mitosis, maintain genomic integrity as well as promote appropriate cell survival or death pathways. Thus, ATM inhibitor can represent a promosing clinical opportunity to hyper-sensitize tumors to chemo/radiotherapy.In vitro: AZD0156 was identified as a first in class orally available ATM inhibitor, showing sub-nanomolar potency in cell based assays of ATM inhibition. Moreover, AZD0156 had selectivities of greater than 1000 fold over other members of the PIKK family enzymes [1]. In vivo: In animal study, AZD0156 displayed excellent preclinical PK properties including oral bioavailability. Additionally, in mouse xenograft models, AZD0156 showed robust efficacy after oral administration when combined with double strand breaks (DSB) inducing agents [1]. Clinical trial: AZD0156 is now undergoing early clinical assessment to investigate the safety and preliminary efficacy at increasing doses alone or in combination with other anti-cancer treatment in patients with advanced cancer [2].
    
    [1] Kurt G. Pike. Identifying high quality, potent and selective inhibitors of ATM kinase: Discovery of AZD0156. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4859.
    [2] https://clinicaltrials. gov/ct2/show/NCT02588105 term=AZD0156&rank=1
- Properties
  - Alternative Name
    
    8-(6-(3-(dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one
    
    CAS Number
    
    1821428-35-6
    
    Molecular Formula
    
    C26H31N5O3
    
    Molecular Weight
    
    461.56
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥23.1 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥5.49 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Kostaras E, Kaserer T, et al. "A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity." Br J Cancer. 2020;10.1038/s41416-020-0889-4. PMID:32439931

AZD0156

AZD0156

Background

We Also Recommend

ML390

Rbin-1