Name: Rbin-1
Price: 352.00 USD

- Overview
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    Background
    
    Rbin-1 is an eukaryotic ribosome assembly inhibitor.All cellular proteins are synthesized by ribosomes, whose biogenesis is a complex multi-step process quickly completed in eukaryotes. Several chemical inhibitors of ribosome function are available, however, potent validated chemical probes are still lacking to analyze the dynamics of eukaryotic ribosome assembly.In vitro: In the mode of action study of Rbin-1, the MDR-sup fission yeast cells was chemically mutagenized and the resistant clones that can grow in the presence of Rbin-1 were isolated. Results found that each of the 13 Rbin-1 resistant clones had one of five different point mutations in the mdn1 gene. It was further confirmed that, using overexpression on plasmids in MDR-sup cells and by replacement of endogenous mdn1 in wild-type cells, all the identified mutations were enough to confer resistance to Rbin-1. In addition, Rbin-1 at 1 μM was able to inhibit the ATPase activity by around 40%. Moreover, the nuclear export of the pre-40S subunits that were tracked using two different reporters, Rps3- GFP and Rps2-GFP, could not be blocked in Rbin-1-treated cells, suggesting that Mdn1 had specific roles in pre-60S ribosome assembly [1]. In vivo: So far, there is no animal in vivo data reported. Clinical trial: Up to now, Rbin-1 is still in the preclinical development stage.
- Properties
  - Alternative Name
    
    3-((2-methylallyl)thio)-5H-[1,2,4]triazino[5,6-b]indole
    
    CAS Number
    
    328023-11-6
    
    Molecular Formula
    
    C13H12N4S
    
    Molecular Weight
    
    256.33
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Rbin-1

Rbin-1

Background

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