Name: Atazanavir sulfate (BMS-232632-05)
Price: 223.00 USD

- Overview
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    Background
    
    Atazanavir sulfate (BMS-232632-05) is the sulfate salt form of atazanavir, a potent protease inhibitor (IP) for the treatment of human immunodeficiency virus 1 (HIV-1) infection, which prevents the formation of mature HIV virions through the selective inhibition of the virus-specific processing of viral gag and gag-pol polyproteins in infected cells. Although it shows strong anti-HIV-1 activity with MIC50 ranging from 2 to 5 nM, atazanavir has lower antiviral activity against HIV-2 isolates. Atazanavir, which is metabolized by the hepatic cytochrome P450 (CYP) system resulting in two main inactive metabolites, is also an inhibitor of CYP3A4 isoenzyme and P-glycoprotein ATP-dependent efflux pump.
- Properties
  - Alternative Name
    
    Atazanavir Bisulfate SaltSee A790051,BMS232632-05; methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric acid
    
    CAS Number
    
    229975-97-7
    
    Molecular Formula
    
    C38H52N6O7·H2SO4
    
    Molecular Weight
    
    802.9
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥28.7 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥4.05 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only