Name: Apoptosis Inhibitor
Price: 180.00 USD

- Overview
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    Background
    
    M50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1] In human Fas-expressing WC8 cells, M50054 inhibited apoptosis by soluble human Fas ligand in vitro cell death assay. M50054 inhibited the apoptotic U937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. M50054 inhibited apoptotic characters such as DNA phosphatidylserine and fragmentation exposure in these cells. These anti-apoptotic effects were dependent on inhibition of caspase-3 activation. Additionally, M50054 significantly inhibited anti-Fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. Alopecia (hair loss) symptoms were also significantly improved with topical treatment with M50054. M50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1]
- Properties
  - Alternative Name
    
    2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione
    
    CAS Number
    
    54135-60-3
    
    Molecular Formula
    
    C13H16O4
    
    Molecular Weight
    
    236.3
    
    Appearance
    
    A solid
    
    Purity
    
    99.70%
    
    Solubility
    
    insoluble in H2O; ≥2.57 mg/mL in EtOH with gentle warming and ultrasonic; ≥9.1 mg/mL in DMSO
    
    Storage
    
    Store at 4°C
    
    * For Research Use Only