Name: Pyronaridine Tetraphosphate
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Pyronaridine (PND), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (MDR) modulator of Pgp-mediated MDR that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (K562 and K562/A02), epidermoid carcinoma (KB and KBV200), breast carcinoma (MCF-7 and MCF-7/ADR), ovarian carcinoma (SKOV3, ES-2 and PA-1), gastric carcinoma (BGC-823), colon carcinoma (LoVo), hepatocellular carcinoma (SMMZ-7721 and QGY-7703), with the half maximal inhibition concentration IC50 values of 8.3 μM, 5.6 μM, 20.8 μM, 14.5 μM, 9.5 μM, 11 μM, 9.7 μM, 12.9 μM, 15.7 μM, 14.9 μM, 21.4 μM, 10.9 μM and 17.1 μM respectively [1].
    
    [1] Qi J, Wang S, Liu G, Peng H, Wang J, Zhu Z, Yang C. Pyronaridine, a novel modulator of P-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. Biochem Biophys Res Commun. 2004 Jul 9;319(4):1124-31.
- Properties
  - Categories
    
    Antimalarial agent
    
    Alternative Name
    
    Malaridine; 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one;phosphoric acid
    
    CAS Number
    
    76748-86-2
    
    Molecular Formula
    
    C29H32ClN5O24H3PO4
    
    Molecular Weight
    
    910.03
    
    Appearance
    
    A solid
    
    Purity
    
    99.48%
    
    Solubility
    
    insoluble in EtOH; ≥12.25 mg/mL in DMSO with gentle warming; ≥8.7 mg/mL in H2O
    
    Storage
    
    Store at RT
    
    SMILES
    
    COC1=CC=C2C(=C(C3=C(N2)C=C(C=C3)Cl)N=C4C=C(C(=O)C(=C4)CN5CCCC5)CN6CCCC6)N1.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O.OP(=O)(O)O
    
    * For Research Use Only
- Reference
  - 1. Villanueva PJ, Martinez A, et al. "Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis."a PLoS One. 2018 Nov 5;13(11):e0206467. PMID:30395606