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Overview
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Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines.
Apoptolidin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.Please contact us at for specific academic pricing.
Background
The apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition; however, recent evidence suggests the existence of a secondary biological target or more complex mode of action.
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