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Overview
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V-ATPase B1 is a protein encoded by the ATP6V1B1 gene which is approximately 56, 8 kDa. V-ATPase B1 is localised to the endomembrane system. It is involved in insulin receptor recycling, innate immune system, metabolism and mTOR signalling pathway. It mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation. V-ATPase B1 is expressed in the cochlea and endolymphatic sac. Mutations in the ATP6V1B1 gene may result in renal tubular acidosis with progressive nerve deafness. STJ96223 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of V-ATPase B1 protein.
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