Name: Anti-UHRF1 antibody
Price: 297.00 USD

Overview
- This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase II alpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 139-298 of human UHRF1 (NP_037414. 3).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  E3 Ubiquitin-Protein Ligase Uhrf1; Inverted Ccaat Box-Binding Protein Of 90 Kda; Nuclear Protein 95; Nuclear Zinc Finger Protein Np95; Hunp95; Hnp95; Ring Finger Protein 106; Ring-Type E3 Ubiquitin Transferase Uhrf1; Transcription Factor Icbp90; Ubiquitin-Like Phd And Ring Finger Domain-Containing Protein 1; Huhrf1; Ubiquitin-Like-Containing Phd And Ring Finger Domains Protein 1 (Gene ID:29128; UniProt:Q96T88)
  
  * For research use only